Dose-response relationship for chemical carcinogenesis by genotoxic agents
نویسندگان
چکیده
منابع مشابه
Do dose response thresholds exist for genotoxic alkylating agents?
The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications for the setting of safe exposure levels. Here we test the hypothesis that direct-acting DNA reactive agents may exhibit thresholded dose responses. We examine the potential mechanisms involved in such thresholded responses, particularly in relation to those of alkylating agents. As alky...
متن کاملDose-response relationship in multistage carcinogenesis: promoters.
Published dose-response curves of promoters of multistage carcinogenesis were selected that met the combined criteria of long study times, multiple doses, and low doses. In rat liver, 12 dose-response studies of 7 different promoters (phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD], clophen A-50 (a polychlorinated biphenyl), alpha-, beta-, and gamma-hexachlorocyclohexane [HCH], and ch...
متن کاملRelationship between the Dose-response Curves for Lethality and Severe Effects for Chemical Warfare Nerve Agents
The U.S. Environmental Protection Agency has developed a categorical logistic regression approach for regressing ordered response categories on one or more factors due to toxicant exposures. This approach can also be used in analyzing chemical warfare agent toxicity. Towards this end, three previous mammalian studies (involving acute inhalation exposures to G-type nerve agents) were reviewed an...
متن کاملGenotoxic and epigenetic chemical carcinogenesis: one process, different mechanisms.
Chemieals that induce cancer in an intact organism are called carcinogens. This term does not differentiale between their vaTiaus modes of action. In this reliiew, Wemer Lutz and Peter Maier make a mechanistic distinction between carcinogens that alter the genetic information and carcinogens that interfere with epigenetic processes. They considercardnogenesis tobe an ongoing, part1y unavoidable...
متن کاملDose response studies of carcinogenesis in rats by nitrosodiethylamine.
A dose-response study was conducted in Fischer rats with nitrosodiethylamine, which was administered in regulated amounts as a solution in drinking water. Groups of 20 female rats each received a different treatment, one group consisted of 12 animals; one of the groups was untreated. The concentrations of the solutions fed ranged from 113 to 0.45 mg/liter at six successive concentrations differ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Sozial- und Pr�ventivmedizin SPM
سال: 1991
ISSN: 0303-8408,1420-911X
DOI: 10.1007/bf01359153